A convenient chemical-microbial method for developing fluorinated pharmaceuticals
نویسندگان
چکیده
منابع مشابه
A convenient chemical-microbial method for developing fluorinated pharmaceuticals.
A significant proportion of pharmaceuticals are fluorinated and selecting the site of fluorine incorporation can be an important beneficial part a drug development process. Here we describe initial experiments aimed at the development of a general method of selecting optimum sites on pro-drug molecules for fluorination, so that metabolic stability may be improved. Several model biphenyl derivat...
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Radioiodinated meta iodobenzylguanidine (MIBG) is one of the important radiopharmaceuticals in Nuclear Medicine. [123/131I]MIBG is used for imaging of Adrenal medulla, studying heart sympathetic nerves, treatment of pheochromacytoma and neuroblastoma. For clinical application, radioiodinated MIBG is prepared through isotopic exchange method, which includes replacement of radioactive iodine in a...
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ژورنال
عنوان ژورنال: Organic & Biomolecular Chemistry
سال: 2013
ISSN: 1477-0520,1477-0539
DOI: 10.1039/c2ob27140k